Gambaran Profil Hematologi Dalam 24 Jam Pertama Pada Pasien Sepsis Di Unit Neonatus RSUD Dr. Pirngadi Medan Tahun 2017-2018
Abstract
Background: Neonatal sepsis is a clinical syndrome on infants aged 28 days or more. According to WHO data on 19th April 2018, estimated 3 million newborns and 1.2 million children suffer from sepsis globally every year. Hematological profile assessment can be used as a clinical guide to diagnose sepsis and early management of patients with early onset, especially in hospitals with limited facilities and the examination data can be obtained faster.
Objective: This study was aimed to determine the hematological profile in sepsis patients in neonatal unit at RSUD Dr. Pirngadi Medan.
Method: This research was a descriptive cross-sectional design. The research sample was selected by total sampling.
Results: The results of the study were found from 74 neonates, 44 (59.5%) were male. Neonates with normal labor were 57 (78.1%) and survived 45 (60.8%). It was found that leukocytes (76.4%), neutrophils (60%), monocytes (87.9%), and hemoglobin (40.3%) were increased.
Conclusion: The hematological profile can be used as a clinical assessment of sepsis at the first 24 hours on neonates. Hematological examination found an increased leukocytes, neutrophils, monocytes, and hemoglobin in neonatal sepsis patients at the first 24 hours.
References
2. Mandal B., Wilkins EG., Dunbaar E., Mayon-White RT. Lecture Notes Penyakit Infeksi. 6th ed. Safitri A, editor. Jakarta: Erlangga; 2008. 9–10 p.
3. Sianturi P, Hasibuan BS, Lubis BM, Azlin E, Tjipta GD. Profil sepsis neonatus di unit perawatan neonatus Adam Malik. Sari Pediatr. 2012;14(2):67–72.
4. Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. The third international consensus definitions for sepsis and septic shock. HHS Public Access. 2016;315(8):801–10.
5. Liu X, Shen Y, Wang H, Ge Q, Fei A, Pan S. Prognostic significance of neutrophil-to-lymphocyte ratio in patients with sepsis: a prospective observational study. Mediators Inflamm. 2016;
6. World Health Organization. Neonatal Mortality [Internet].2019. Available from: https://www.who.int/gho/child_health/mortality/neonatal_text/en/
7. World Health Organization. Sepsis [Internet]. 2018. Available from: https://www.who.int/news-room/fact-sheets/detail/sepsis
8. Marcdante KJ, Kliegman RM, Jenson HB, Behrman RE. Nelson Ilmu Kesehatan Anak Essensial. 6th ed. Suryawan A, Chairulfatah A, Pulungan AB, Endaryanto A, Pudjiadi A, Kurniawan A, et al., editors. Singapore: Elsevier; 2014. 284–286 p.
9. Mulya Rahma Karyanti. Pitfalls of Laboratory Interpretation for Infection. In: Trihono PP, Djer MM, Hendarto A, Prawitasari T, editors. Pitfalls in Pediatric Practices. Jakarta: Ikatan Dokter Anak Indonesia; 2012. p. 1–29.
10. Profil Kesehatan Provinsi Kepulauan Bangka Belitung. Depkes. 2017.
11. Jager CP de, Wijk PT van, Jongh-Leuvenink RBMJ de, Poll T van der, Peter C Wever. Lymphocytopenia and neutrophil-lymphocyte count ratio predict bacteremia better than conventional infection markers in an emergency care uni. Crit Care. 2010;
12. Adriani R, Yantri E, Mariko R. Peran sistem skoring hematologi dalam diagnosis awal sepsis neonatorum awitan dini. Sari Pediatr. 2018;20(1):17–23.
13. Holub M, Beran O, Kaspříková N, Chalupa P. Neutrophil to lymphocyte count ratio as a biomarker of bacterial infections. Cent Eur J Med.2012;258-261
14. Fitriani EC, Amalia Y, Diah Andriana. Hubungan kadar dan hitung jenis leukosit pada angka mortalitas neonatus dan bayi akibat sepsis di Kabupaten Malang. Jurnal Bio Komplementer Medicine. 2019;6(3):183–9.
15. Nur’izzati, Maani H, Husni. Gambaran hematologic scoring system pada tersangka sepsis neonatorum. J Kesehat Andalas. 2018;7(3):1–5.
16. Wilar R, Antolis Y, N.N.Tatura S, Gunawan S. Jumlah trombosit dan mean platelet volume sebagai faktor prognosis pada sepsis neonatorum. Sari Pediatr. 2010;12(1):53–7.
17. Putri IA, Aryati, Lestari AAW. Peranaan immature/total (i/t) ratio, jumlah leukosit dan procalcitonin (pct) dalam menegakkan diagnosis sepsis. Airlangga; 2016.
18. Arumaningsih F, Suhariyadi. Hubungan nilai sel polimorfonuklear (neutrofil,eosinofil,dan basofil) dengan kadar procalcitonin pada pasien sepsis bakteri. Anal Kesehat Sains. 2018;7(2):609–17.
19. Roeslani RD, Amir I, Nasrulloh MH, Suryani. Penelitian awal faktor risiko sepsis neonatorum awitan dini. Sari Pediatr. 2013;14(6):363–8.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.