Hubungan Usia Dengan Estrogen Receptor Pada Penderita Kanker Payudara di RSUD Dr. Pirngadi Medan Tahun 2018
Abstract
Background: Breast cancer is a malignancy in breast tissue that can be originated from ductal epithelium and lobules. It is the main cause of death from cancer suffered by women in the world. Age and hormonal are important risk factors for breast cancer where the longer a person is exposed to estrogen, the higher is the risk for breast cancer. The estrogen receptor is one of the main prognostic and predictive factors examined in breast cancer and can be determinant for hormonal therapy.
Objectives: This study aimed to discover the relation between age and estrogen receptor in breast cancer patients of RSUD Dr.Pirngadi Medan in 2018.
Methods: This research was an analytical study with a cross-sectional design. The research sample was 96 breast cancer patients by medical records of RSUD Dr.Pirngadi Medan in 2018 collected by a consecutive sampling method. Analysis of the data in this study was done by univariate to describe the characteristics of research subjects, while bivariate analysis used the chi-square test method to analyze the relationship between age and estrogen receptor.
Results: The patients with breast cancer in RSUD Dr.Pirngadi Medan 2018 was mostly >40 years old (79.2%), with negative estrogen receptor hormonal status (53%), status was married (99%), and the highest level of education was high school (54.2%). The results of the study showed that there was a relationship between age and estrogen receptor in breast cancer patients with p-value =0.007 (p value<0,05).
Conclusion: There was a significant relationship between age and estrogen receptors and estrogen receptors in breast cancer patients in RSUD Dr.Pirngadi Medan 2018.
References
2. Kementrian Kesehatan Republik Indonesia. Profil Kesehatan Indonesia Tahun 2016. Jakarta; 2017. hal 2
3. Komite Penanggulangan Kanker Nasional. Panduan Penatalaksanaan Kanker Payudara. Jakarta; Tersedia pada http://kanker.kemkes.go.id/guidelines_read.php?id=2&cancer=1
4. Savitri A. Kupas Tuntas Kanker Payudara,Leher Rahim & Rahim. Mona, editor. Yogyakarta: Pustaka Baru Press; 2015.
5. World Health Organization. Breast [Internet]. 2018. Tersedia pada: http://gco.iarc.fr/today
6. Cancer Country Profiles [Internet]. World Health Organization. 2019. Tersedia pada: https://gco.iarc.fr/today/home
7. Jong D. Buku Ajar Ilmu Bedah. 3rd ed. Sjamsuhidajat R, editor. Jakarta: EGC; 2012.hal.479-80
8. Fujin C, Zhongli C, Minshan C. Buku Ajar Onkologi Klinis. Edisi 2. Jakarta: Fakultas Kedokteran Indonesia.hal.366–82
9. Bickley LS. Bates Buku Ajar Pemeriksaan Fisik dan Riwayat Kesehatan. Edisi 8. Hartono A, editor. Jakarta: EGC; 2012. hal.309-10
10. Putri N. Hubungan Antara Usia dan Body Mass Index(BMI) dengan Fenotip Molekuler Estrogen Receptor (ER) pada Pasien Invasive Breast Carsinoma of No Special Type(NST) di Rumah Sakit PKU Muhammadiyah Surakarta [tesis]. Universitas Muhammadiyah Surakarta; 2018.
11. Chorida L. Densitas Mamografi Metode Nilai Ambang, Kadar Estradiol, dan Polimorfisme Receptor Estrogen Sebagai Prediktor Kanker Payudara [disertasi]. Universitas Gadjah Mada; 2013.
12. Alzaman A. Correlation Between Hormone Receptor Status and Age, and its Prognostic Implications in Breast Cancer Patients in Bahrain. Saudi Med. 2016;37(1).
13. Estetika S, Harahap WA, Deddy Saputra. Pengaruh Faktor Resiko Terhadap Ekspresi Receptor Estrogen Pada Penderita Kanker Payudara di Kota Padang. J Kesehat Andalas. 2018;7(4).
14. Yanti M. Faktor Risiko Kanker Payudara Pada Wanita di Poliklinik Bedah RSUP Dr. M. Djamil Padang Tahun 2016. Universitas Andalas; 2016.
15. Lincoln J, Wilensky. Kanker Payudara Diagnosis dan Solusinya. Jakarta: Prestasi Pustakaraya; 2008.
16. Firasi AA, Yudhanto E. Hubungan Usia Terhadap Derajat Diferensiasi Kanker Payudara Pada Wanita. J Kedokt Diponegoro. 2016;5(4).
17. Payne SJL, Bowen RL, Jones JL, C A Wells. Predictive Markers In Breast Cancer-the Present. J Compil. 2008;52:82–90.
18. Suparman E.Peran Estrogen Dan Progesteron Terhadap Kanker Payudara. Junal Biomedik (JBM). 2014;6(3):141–8.
19. Sulistiyowati. Stadium Kanker Payudara Ditinjau Dari Usia Dan Paritas Ibu Di Unit Rawat Jalan RSUD Dr. Soegiri Kabupaten Lamongan. Surya. 2012;3(13).
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