Acute Kidney Injury (AKI) Pasca Primary Coronary Intervention (PCI) pada Pasien STEMI

  • Erik Jaya Gunawan Medical Doctor Profession Department, Fakultas Kedokteran, Universitas Ciputra Surabaya https://orcid.org/0000-0002-7739-4568
  • Isnaini Isnaini KSM Jantung dan Pembuluh Darah, Rumah Sakit Umum Daerah Dr. M. Soewandhie Surabaya
  • Salmon Charles P. T. Siahaan Medical Doctor Profession Department, Fakultas Kedokteran, Universitas Ciputra Surabaya
  • Yuswanto Setyawan Medicine Department, Fakultas Kedokteran, Universitas Ciputra Surabaya
  • Imelda Ritunga Medicine Department, Fakultas Kedokteran, Universitas Ciputra Surabaya
Keywords: AKI, PCI, score

Abstract

Background: Treating STEMI with PCI not only has a positive impact on patients, but also the risk of complications. A complication that can occur is AKI. The aim of this case report is to increase clinician awareness by analyzing the risk of AKI after PCI in order to reduce patient morbidity and mortality rates.

Case: A 58-years old-man, with a history of diabetes mellitus, dyslipidemia, and a previous heart attack, came to the emergency department because of chest pain. The patient experienced STEMI and received fibrinolytic therapy. After 3 days of treatment, the condition worsened and the patient experienced shortness of breath (pulmonary edema). The patient was referred to RSUD Dr. M. Soewandhie Surabaya to undergo PCI. Two days after PCI, there were clinical signs of AKI. The patient was prepared for Renal Replacement Therapy (RRT), but the patient experienced cardiac arrest and was declared dead.

Discussion: AKI after PCI involves various complex mechanisms. Several factors that can increase the probability of AKI after PCI in this case are a history of diabetes mellitus, previous decline in kidney function, and pulmonary edema. Technique factors such as transfemoral PCI and the amount of contrast volume used also have an influence on the incidence of AKI after PCI and need to be studied further. Risk factors in patients can be used to determine clinical scores, such as the Mehran, ADVANCIS, or ACEF-MDRD scores to predict the probability of AKI after PCI.

Conclusion: AKI after PCI is a frequent complication and calculations using clinical scores can be applied to predict this event.

Author Biography

Isnaini Isnaini, KSM Jantung dan Pembuluh Darah, Rumah Sakit Umum Daerah Dr. M. Soewandhie Surabaya

Departement Medical Doctor Profession, Fakultas Kedokteran, Universitas Ciputra Surabaya

References

1. Virani SS, Alonso A, Benjamin EJ, et al. Heart Disease and Stroke Statistics—2020 Update: A Report From the American Heart Association. Circulation 2020;141(9).
2. Ralapanawa U, Sivakanesan R. Epidemiology and the Magnitude of Coronary Artery Disease and Acute Coronary Syndrome: A Narrative Review. J Epidemiol Glob Health 2021;11(2):169.
3. Tim Riskesdas. Laporan Nasional Riskesdas 2018. Jakarta: 2019;
4. Byrne RA, Rossello X, Coughlan JJ, et al. 2023 ESC Guidelines for the management of acute coronary syndromes. Eur Heart J 2023;44(38):3720–3826.
5. Kellum JA, Lameire N, Aspelin P, et al. Kidney disease: Improving global outcomes (KDIGO) acute kidney injury work group. KDIGO clinical practice guideline for acute kidney injury. Kidney Int Suppl (2011). 2012;2(1):1–138.
6. Carande EJ, Brown K, Jackson D, et al. Acute Kidney Injury Following Percutaneous Coronary Intervention for Acute Coronary Syndrome: Incidence, Aetiology, Risk Factors and Outcomes. Angiology 2022;73(2):139–145.
7. Tsai TT, Patel UD, Chang TI, et al. Contemporary Incidence, Predictors, and Outcomes of Acute Kidney Injury in Patients Undergoing Percutaneous Coronary Interventions. JACC Cardiovasc Interv 2014;7(1):1–9.
8. El-Ahmadi A, Abassi MS, Andersson HB, et al. Acute kidney injury – A frequent and serious complication after primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction. PLoS One 2019;14(12):e0226625.
9. Jiang M-Y. Impact of Acute Kidney Injury and Baseline Renal Impairment on Prognosis Among Patients Undergoing Percutaneous Coronary Intervention. Acta Cardiol Sin 2020;36(3):223–232.
10. Go AS, Tan TC, Parikh R V., et al. Timing of AKI after urgent percutaneous coronary intervention and clinical outcomes: a high-dimensional propensity score analysis. BMC Nephrol 2021;22(1):300.
11. Birkelo BC, Pannu N, Siew ED. Overview of Diagnostic Criteria and Epidemiology of Acute Kidney Injury and Acute Kidney Disease in the Critically Ill Patient. Clinical Journal of the American Society of Nephrology 2022;17(5):717–735.
12. Kellum JA. Diagnostic Criteria for Acute Kidney Injury. Crit Care Clin 2015;31(4):621–632.
13. Makris K, Spanou L. Acute Kidney Injury: Definition, Pathophysiology and Clinical Phenotypes. Clin Biochem Rev 2016;37(2):85–98.
14. Turgut F, Awad A, Abdel-Rahman E. Acute Kidney Injury: Medical Causes and Pathogenesis. J Clin Med 2023;12(1):375.
15. Zhang Y, Liu D, Zhou Y, Lou J. Acute Kidney Injury in Patients with Acute Coronary Syndrome after Percutaneous Coronary Intervention: Pathophysiologies, Risk Factors, and Preventive Measures. Cardiology 2021;146(6):678–689.
16. Xu F, Cheng H, Yue T, Ye N, Zhang H, Chen Y. Derivation and validation of a prediction score for acute kidney injury secondary to acute myocardial infarction in Chinese patients. BMC Nephrol 2019;20(1):195.
17. Araujo GN, Pivatto Junior F, Fuhr B, et al. Simplifying contrast-induced acute kidney injury prediction after primary percutaneous coronary intervention: the age, creatinine and ejection fraction score. Cardiovasc Interv Ther 2018;33(3):224–231.
18. Kooiman J, Seth M, Dixon S, et al. Risk of Acute Kidney Injury After Percutaneous Coronary Interventions Using Radial Versus Femoral Vascular Access. Circ Cardiovasc Interv 2014;7(2):190–198.
19. Mehran R, Aymong ED, Nikolsky E, et al. A simple risk score for prediction of contrast-induced nephropathy after percutaneous coronary intervention. J Am Coll Cardiol 2004;44(7):1393–1399.
20. Chatterjee S, Kundu A, Mukherjee D, et al. Risk of contrast‐induced acute kidney injury in ST‐elevation myocardial infarction patients undergoing multi‐vessel intervention‐meta‐analysis of randomized trials and risk prediction modeling study using observational data. Catheterization and Cardiovascular Interventions 2017;90(2):205–212.
21. Fan P-C, Chen T-H, Lee C-C, Tsai T-Y, Chen Y-C, Chang C-H. ADVANCIS Score Predicts Acute Kidney Injury After Percutaneous Coronary Intervention for Acute Coronary Syndrome. Int J Med Sci 2018;15(5):528–535.
Published
2024-08-06
How to Cite
Gunawan, E., Isnaini, I., Siahaan, S., Setyawan, Y., & Ritunga, I. (2024). Acute Kidney Injury (AKI) Pasca Primary Coronary Intervention (PCI) pada Pasien STEMI. Nommensen Journal of Medicine, 10(1), 12-16. https://doi.org/https://doi.org/10.36655/njm.v10i1.1376